Cell-based immunotherapy is an emerging development in personalized cancer treatment where one application includes utilizing engineered immune cells that target cancer cells and engage the immune system to eradicate the disease. During preclinical development of these immunotherapies, it is essential to visualize cell distribution to both target and non-target tissues as well as gain critical information on immune engagement.
In this webinar, Dr. Matt Silva, CEO of EMIT Imaging shows how whole-body cryo-fluorescence tomography (CFT) imaging will revolutionize cell and immunotherapy research. CFT enables multiplexing of cell tracking and localization with target and non-target tissue with immune activation via constitutive or imaging probe fluorescence. He covers the fundamentals of CFT imaging via the EMIT XerraTM system and reviews examples of recent work on the platform.
Key Topics Include:
- Introduction to Cryo-Fluorescence Tomography (CFT) for immunotherapy research
- Overview of capabilities of the EMIT Xerra system
- Real-world examples and applications of CFT for cancer research
Cryo-Fluorescence Tomography is a volumetric tissue imaging technique used to visualize the 3D biodistribution of fluorescently-labeled molecules or the expression of fluorescent reporter proteins with high resolution and sensitivity. Anatomical and molecular images are co-registered, providing precise localization information of drugs, delivery vehicles, proteins, and other biochemical processes in whole animals and tissues.
Cryo-Fluorescence Tomography (CFT) has been widely adopted by researchers across industry and academia. The exceptional detail provided by CFT has proven critical in advancing research areas such as gene and cell therapy, drug discovery and delivery, oncology and immunotherapy, and neurology.
Cryo-Fluorescence Tomography fits seamlessly into existing workflows and, in many cases, can act as a replacement for in vivo optical imaging modalities. CFT provides higher resolution, higher sensitivity, and enhanced anatomical information compared to in vivo FLI, often correcting misinterpretations identified with other methods. Download the case study to learn more.
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