Cryo-Fluorescence Tomography (CFT) is a novel, 3D approach to imaging drug distribution and protein expression in whole animals and large tissue samples. EMIT Imaging offers both instrumentation and services via our imaging platform, XerraTM, a high-resolution, high-sensitivity preclinical imaging tool designed to advance discoveries in biological and drug research. See what you’re missing with standard 2D in vivo fluorescence imaging techniques and utilize CFT to better visualize:
- Whole-body drug distribution and delivery
- Screening candidate drugs and delivery systems
- Whole-body therapeutic protein expression
- Multiplexed co-localization of drug with targets
- On and off target tissue identification
CFT Instrumentation and Services
Xerra: CFT Instrumentation
Xerra is EMIT Imaging's flagship imaging platform. Xerra fully automates the CFT workflow enabling you to run samples in-house with ease, and provides unmatched visualization of drug distribution and protein expression in whole-animals.
EMIT Imaging offers CFT Services performed in-house, at our state-of-the-art lab in Baltimore, Maryland. Simply freeze samples, ship them directly to us, and let EMIT handle the rest.
Drug Discovery & Delivery
CFT is important for ADME (absorption distribution, metabolism, excretion) and drug distribution, pharmacokinetic, and pharmacodynamic studies.
(CFT) and Xerra™, a 3D imaging technology allows whole-body detection and visualization of vector biodistribution and vector-mediated gene expression, in high resolution and with high sensitivity.
CFT can play a key role for studying tumor models including microenvironments, tumor heterogeneity, metastatic spread, and expression of specific biomarkers.
The 3D CFT maps of fluorescence reporters can aid in visualization of cell tracking, drug delivery, and pharmacodynamics in the brain.