Neuroscience
Visualization of cell tracking, drug delivery, and pharmacodynamics in the brain.
CFT for neuroscience research
Cryo-Fluorescence Tomography (CFT) is a powerful imaging tool for neuroscience, where fluorescence reporters can aid in visualization of cell tracking, drug delivery, and pharmacodynamics in the brain. CFT can be used to study the physiology, anatomy, and molecular biology of the brain. In addition, neurodegenerative diseases and other pathologies that affect different regions of the brain and neurological pathways can also be visualized.
EMIT Imaging's visualization tools make CFT data easier to explore and collaborate on, with a full range of options to fit different user types and use cases.
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Intracerebral GFP-expressing cell injection
Findings: Imaging of isolated tissue samples with CFT provides higher resolution than whole-body. In this example, a mouse head was intracerebrally injected with GFP-expressing cells and imaged at 20 µm.
Cell-specific fluorescence reporter imaging
Findings: GAD67-GFP (line G42) mice selectively express enhanced green fluorescent protein (EGFP) in the parvalbumin (Pv)-expressing subclass of basket interneurons (soma, dendrites, and axons) and also in putative presynaptic boutons.
