Mouse brain images 1 to 12 hours after injection of a Cy7 conjugated therapeutic.
Delivery of antisense (ASOs) labeled with Cy7 are evaluated in mouse brains.
CFT, a powerful tool in PK studies
Cryo-Fluorescence Tomography (CFT) allows for high-resolution visual feedback, a powerful tool in pharmacokinetics studies, researchers can precisely track the movement of dyes and molecules through the body. Data can be used for the whole animal or segmented to view individual regions or organs. Data can be viewed as an image/3D rendering over time and quantified as a time course plot.
Quantify and trace drug movement in one step
Photodynamic Therapy and Cyro-Fluorescence Tomography
Cryo-Fluorescence Tomography (CFT) is a powerful imaging tool for neuroscience. CFT can be used to study the physiology, anatomy, and molecular biology of the brain. In addition, neurodegenerative diseases and other pathologies that affect different regions of the brain and neurological pathways can also be visualized with CFT. CFT can help elucidate anatomy, disease etiology and progression via fluorescence visualization. The 3D CFT maps of fluorescence reporters can aid in visualization of cell tracking, drug delivery, and pharmacodynamics in the brain.
PDT – new, exciting, trending
Photodynamic therapy (PDT) is a new technique based on simple biology. Levels of Protoporphyrin IX (PPIX), a blood protein, are high in malignant gliomas and meningioma (types of brain and brain/spinal cord tumors, respectively). PPIX is made from Aminolevulinic acid (ALA). When you flood the brain with ALA, a lot of PPIX is produced. Exposing PPIX to light of a particular wavelength excites it – making it give off by-products (reactive oxygen species) that can be quantified and traced. This is PDT. PDT is an exciting and trending technique because it can be used to treat cancer and guide brain surgery to remove tumors.