Cryo-Fluorescence Tomography
A transformative 3D imaging tool to monitor drug PK/PD, biodistribution, and protein expression at high resolution and high sensitivity.
Contact UsWhat is CFT?
Cryo-Fluorescence Tomography (CFT) is an ex vivo, volumetric tissue imaging technique used to monitor the pharmacokinetics and pharmacodynamics (PK/PD) of drugs, delivery vehicles, and proteins with high resolution and sensitivity. White-light, anatomical images are acquired alongside fluorescence images that are displayed in a 3D visualization of drug biodistribution and protein expression.
CFT is complementary
Prior to CFT, an imaging gap existed between cellular microscopy and whole-body imaging modalities like MRI, PET, and CT. CFT is the bridge between cellular and whole-body imaging, all on one platform.
High-resolution and high-sensitivity CFT allows for detailed imaging of large tissue samples. In comparison, other imaging modalities can only focus on subcellular structures or low-resolution images of whole bodies or specific regions.
Cryo-Fluorescence Tomography
2D Fluorescence
SPECT/CT
CFT expands imaging
Optical and nuclear imaging methods are critical tools in research, however both have limitations. 2D optical imaging is easy to implement but is limited to low-resolution, surface images lacking anatomical information. Nuclear imaging techniques are 3D, but also provide low resolution with limited anatomical information, and require dedicated expertise and facilities that are impractical for some laboratories.
CFT increases the value of imaging studies by expanding the information provided. CFT can be used at key time points to describe PK/PD in more detail, providing both high-resolution anatomical and molecular information that improves the interpretation of optical and nuclear methods.
