Gene & cell therapy
Visualization of vector biodistribution and vector-mediated gene expression.
CFT in gene and cell therapy
New vectors are in development to improve their efficacy, including biodistribution and transduction, while minimizing off-target or safety liabilities. Unbiased visualization of vector biodistribution and subsequent gene transduction in preclinical models is crucial in early-stage research; however, these critical studies are challenging using standard imaging modalities.
See what you're missing with Cryo-Fluorescence Tomography (CFT) and Xerra™, a 3D imaging technology that allows whole-body detection and visualization of vector biodistribution and vector-mediated gene expression, in high resolution and with high sensitivity.
EMIT Imaging's visualization tools make CFT data easier to explore and collaborate on, with a full range of options to fit different user types and use cases.
Contact us to identify the best visualization tool for your team and receive a demo →
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AAV-mediated protein expression
Findings: 3D CFT visualization of AAV vector biodistribution and expression following IV administration.
Whole-body distribution of labeled ASO
Findings: CFT enhances data from 2D in vivo FLI by addressing its depth and resolution limitations.
Whole-body transduction
Findings: CFT visualization of whole-body transduction and expression by AAV9 and AAV7.
Regional transduction
Findings: CFT identified several tissues with AAV transduction and protein expression.
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Open the cardiac or neurotropic AAV dataset and page through slices, toggle fluorescence channels, and rotate the reconstructed volume. Nothing to download and nothing to install.