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This case study highlights the role of EMIT Imaging and Cryo-Fluorescence Tomography (CFT) in analyzing AAV7 and AAV9 whole animal drug biodistribution. The data was recently published by REGENXBIO, Inc. in the Journal of Virology and explored the potential of AAV7 as a gene therapy vector, comparing its biodistribution with AAV9 in mice following intravenous administration. CFT was used extensively in this research to analyze whole-body vector biodistribution and to guide IHC and PCR methods.

Download the case study below to learn how EMIT Imaging and CFT can help you discover more from your gene therapy research.

Reference: Yost SA, Firlar E, Glenn JD, Carroll HB, Foltz S, Giles AR, Egley JM, Firnberg E, Cho S, Nguyen T, Henry WM, Janczura KJ, Bruder J, Liu Y, Danos O, Karumuthil-Melethil S, Pannem S, Yost V, Engelson Y, Kaelber JT, Dimant H, Smith JB, Mercer AC. 2023. Characterization and biodistribution of under-employed gene therapy vector AAV7. J Virol 97:e01163-23.